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Article

Lysostaphin-resistant variants of Staphylococcus aureus demonstrate reduced fitness in vitro and in vivo.

Antimicrobial agents and chemotherapy - 1 Feb 2007

Kusuma Caroline, Jadanova Anna, Chanturiya Tanya, Kokai-Kun John F

Abstract excerpt

Lysostaphin is under development as a therapy for serious staphylococcal infections. During preclinical development, lysostaphin-resistant Staphylococcus aureus variants have occasionally been reported in vitro and in vivo. The acquisition of resistance to this drug, however, leads to a significant increase in beta-lactam antibiotic susceptibility, rendering methicillin-resistant S. aureus (MRSA) strains...

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PMID: 17101683
DOI: 10.1128/AAC.00786-06
PMCID: PMC1797764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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