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Article

In-vitro and in-vivo selection of Staphylococcus aureus mutants resistant to ciprofloxacin.

The Journal of antimicrobial chemotherapy - 1 Jan 1995

Doss S A, Tillotson G S, Barg N L, Amyes S G

Abstract excerpt

Staphylococcus aureus mutants resistant to ciprofloxacin were selected both in vitro and in vivo. In-vitro selection was achieved by incubating two strains of S. aureus (MICs of ciprofloxacin of 0.5 and 4 mg/L respectively) in the presence of ciprofloxacin in concentrations equivalent to 1/2 x MIC for 24 h and isolating the mutants on agar containing the quinolone at 1, 2 or 5 x MIC. Stably-resistant mutants of...

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Source

Identifiers

PMID: 7768787
DOI: 10.1093/jac/35.1.95

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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