In-vitro and in-vivo selection of Staphylococcus aureus mutants resistant to ciprofloxacin.

doi:10.1093/jac/35.1.95

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Article

In-vitro and in-vivo selection of Staphylococcus aureus mutants resistant to ciprofloxacin.

The Journal of antimicrobial chemotherapy - 1 Jan 1995

Doss S A, Tillotson G S, Barg N L, Amyes S G

Abstract excerpt

Staphylococcus aureus mutants resistant to ciprofloxacin were selected both in vitro and in vivo. In-vitro selection was achieved by incubating two strains of S. aureus (MICs of ciprofloxacin of 0.5 and 4 mg/L respectively) in the presence of ciprofloxacin in concentrations equivalent to 1/2 x MI...

Topics

Abscess
Animals
Ciprofloxacin
Colony Count, Microbial
Drug Resistance, Microbial
Mice
Microbial Sensitivity Tests
Mutation
Staphylococcal Infections
Staphylococcus aureus

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