Article
Cystic fibrosis-type mutational analysis in the ATP-binding cassette transporter signature of human P-glycoprotein MDR1.
The Journal of biological chemistry - 12 Aug 1994
Hoof T, Demmer A, Hadam M R, Riordan J R, Tümmler B
Abstract excerpt
Members of the ATP-binding cassette transporter superfamily such as the P-glycoproteins (MDR) and the cystic fibrosis transmembrane conductance regulator (CFTR) share conserved sequence motifs in their nucleotide binding fold that are the major targets for CFTR mutations in patients with cystic f...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenosine Triphosphate
- Affinity Labels
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Carrier Proteins
- Cricetinae
- Cystic Fibrosis
- DNA Mutational Analysis
- Drug Resistance
- Humans
- Membrane Glycoproteins
- Molecular Sequence Data
- Phenotype
- Photochemistry
- RNA, Messenger