Article
Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters.
Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2008
Jordan I King, Kota Karthik C, Cui Guiying, Thompson Christopher H, McCarty Nael A
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) is a member of the ATP-binding cassette (ABC) transporter superfamily, an ancient family of proteins found in all phyla. In nearly all cases, ABC proteins are transporters that couple the hydrolysis of ATP to the transmembrane movement of substrate via an alternating access mechanism. In contrast, CFTR is best known for its activity as an...
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