Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay.

doi:10.1371/journal.pgen.0030039

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Article

Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay.

PLoS genetics - 9 Mar 2007

Jeong Hotcherl, Herskowitz Ira, Kroetz Deanna L, Rine Jasper

Abstract excerpt

The human ABCB1 (MDR1)-encoded multidrug transporter P-glycoprotein (P-gp) plays a major role in disposition and efficacy of a broad range of drugs including anticancer agents. ABCB1 polymorphisms could therefore determine interindividual variability in resistance to these drugs. To test this hypothesis we developed a Saccharomyces-based assay for evaluating the functional significance of ABCB1 polymorphisms. The...

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PMID: 17352537
DOI: 10.1371/journal.pgen.0030039
PMCID: PMC1817653

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.