Revisiting the effects of MDR1 Variants using computational approaches

Abstract excerpt

P-glycoprotein, encoded by the MDR1 gene, is an ATP-dependent pump that exports various substances out of cells. Its overexpression is related to multi drug resistance in many cancers. Numerous studies explored the effects of MDR1 variants on p-glycoprotein expression and function, and on patient survivability. T1236C, T2677C and T3435C are prevalent MDR1 variants that are the most widely studied, typically in-vit...

Topics

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• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Computational Biology
• Gene Expression Regulation, Neoplastic
• Neoplasms
• Polymorphism, Single Nucleotide
• RNA Folding
• RNA, Messenger

Identifiers and source

Literature Corpus work

8a11ee72-7467-5bd6-92fe-f9c829e2e6f3

DOI

10.1101/2023.09.02.23294978