Article
Polymorphisms in the interleukin-4 and IL-4 receptor genes and multiple sclerosis: a study in Spanish-Basque, Northern Irish and Belgian populations.
International journal of immunogenetics - 1 Dec 2005
Suppiah V, Goris A, Alloza I, Heggarty S, Dubois B, Carton H, Antigüedad A, Mendibe M, McDonnell G, Droogan A, Hawkins S, Graham C, Vandenbroeck K
Abstract excerpt
Cytokine gene polymorphisms are known to influence susceptibility and disease course of many autoimmune diseases. Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system white matter characterized by inflammation, demyelination and axonal damage. We analysed both the well-known intronic variable number of tandem repeat (VNTR) and +33 C/T single-nucleotide polymorphisms (SNP) in the...
Topics
- Adult
- Europe
- Female
- Genetic Predisposition to Disease
- Humans
- Interleukin-4
- Male
- Multiple Sclerosis
- Polymorphism, Single Nucleotide
- Receptors, Interleukin-4