Article
[Cancers of the kidney: multiple drug resistance].
Bulletin du cancer - 1 Oct 1993
Oudard S, Lizard G, Roignot P, Poupon M F
Abstract excerpt
The treatment of kidney cancers raise difficult problems. Usual treatments combining surgery, radiation therapy, chemotherapy and hormonotherapy are poorly effective. The immunotherapy gave only an objective response rate of 25% in metastatic renal cell carcinomas. Among cellular resistance mechanisms of renal carcinoma, the multi-drug resistance (MDR) phenotype and the glutathione redox cycle have been studied....
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Carrier Proteins
- Combined Modality Therapy
- Drug Resistance
- Gene Expression Regulation, Neoplastic
- Glutathione Transferase
- Humans
- Immunotherapy
- Kidney Neoplasms
- Membrane Glycoproteins