[MDR1 (ABCB1) gene encoding glycoprotein P (P-gp), a member of ABC transporter superfamily: consequences for therapy and progression of neoplastic diseases].

Abstract excerpt

Glycoprotein P (P-gp) is a membrane protein belonging to the ABC transporter superfamily. As ATP-dependent pump it extrudes lipophilic particles out of the cell. P-gp was discovered in Chinese hamster ovary cells (CHO) where causing resistance to anticancer drugs. In a physiological state it is present in secretory organs and contribute to tissue barriers. P-gp transports wide variety of structurally diverse...

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