Linkage disequilibrium in the insulin gene region: size variation at the 5' flanking polymorphism and bimodality among "class I" alleles.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Linkage disequilibrium in the insulin gene region: size variation at the 5' flanking polymorphism and bimodality among "class I" alleles.

American journal of human genetics - 1 Sept 1994

McGinnis R E, Spielman R S

Abstract excerpt

The 5' flanking polymorphism (5'FP), a hypervariable region at the 5' end of the insulin gene, has "class 1" alleles (650-900 bp long) that are in positive linkage disequilibrium with insulin-dependent diabetes mellitus (IDDM). We report that precise sizing of the 5'FP yields a bimodal frequency...

Topics

Adult
Alleles
Child
Chromosomes, Human, Pair 11
Diabetes Mellitus, Type 1
Electrophoresis, Agar Gel
Female
Gene Frequency
Genetic Variation
Haplotypes
Humans
Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Like Growth Factor II

Linkage Disequilibrium

Male

Polymorphism, Restriction Fragment Length

Repetitive Sequences, Nucleic Acid

Tyrosine 3-Monooxygenase

Source

Open in PubMed Open full text

Identifiers

PMID: 7915880
PMCID: PMC1918400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7915880-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linkage disequilibrium in the insulin gene region: size variation at the 5' flanking polymorphism and bimodality among "class I" alleles.PMID 7915880Read ↗

Insulin gene 5' flanking polymorphism. Length of class 1 alleles in number of repeat units.Semantic proximity Read ↗

Global haplotype diversity in the human insulin gene region.Semantic proximity Read ↗

Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene.Semantic proximity Read ↗

Juxtaposed short sequence repeat types and haplotypes near exon 3 of the insulin receptor locus among Mexican Americans.Semantic proximity Read ↗

Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene.Semantic proximity Read ↗

Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.Semantic proximity Read ↗

Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population.Semantic proximity Read ↗

Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes.Semantic proximity Read ↗

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.Semantic proximity Read ↗

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.Semantic proximity Read ↗

Multiple DNA variant association analysis: application to the insulin gene region in type I diabetes.Semantic proximity Read ↗

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.