Article
Expression of NMDAR1-1a (N598Q)/NMDAR2A receptors results in decreased cell mortality.
European journal of pharmacology - 15 Feb 1994
Cik M, Chazot P L, Stephenson F A
Abstract excerpt
Transient expression of wild-type N-methyl-D-aspartate, NMDAR1-1a/NMDAR2A heteromeric receptors, in mammalian cells yields cell death which was prevented by the inclusion of NMDA receptor antagonists in the cell culture media post-transfection. Transient expression of mutant NMDAR1-1a (N598Q)/NMDAR2A receptors resulted in a significant decrease in the percentage of cell death post-transfection. This mutation has...
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