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Article

Role of NMDA receptor functional domains in excitatory cell death.

Neuropharmacology - 1 Sept 2000

Rameau G A, Akaneya Y, Chiu L, Ziff E B

Abstract excerpt

The mechanisms by which the NMDA receptor (NMDAR) induces excitotoxicity were investigated using a novel assay. We quantitated the capacity of wild type and mutant receptors for cell killing in CHO cells and cultured cortical neurons by measuring the activity of a co-transfected firefly luciferase expression plasmid. NR1 subunit pore mutations that block Ca(2+) influx, and deletion of the NR1 cytoplasmic...

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Identifiers

PMID: 10974309
DOI: 10.1016/s0028-3908(00)00066-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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