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Article

Role of NMDA receptor functional domains in excitatory cell death.

Neuropharmacology - 1 Sept 2000

Rameau G A, Akaneya Y, Chiu L, Ziff E B

Abstract excerpt

The mechanisms by which the NMDA receptor (NMDAR) induces excitotoxicity were investigated using a novel assay. We quantitated the capacity of wild type and mutant receptors for cell killing in CHO cells and cultured cortical neurons by measuring the activity of a co-transfected firefly luciferase expression plasmid. NR1 subunit pore mutations that block Ca(2+) influx, and deletion of the NR1 cytoplasmic...

Topics

Animals
CHO Cells
Cell Death
Cell Survival
Cerebral Cortex
Cricetinae
DNA
Excitatory Amino Acids
Luciferases
Mutation
Neurons
Plasmids
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, N-Methyl-D-Aspartate

Transfection

Source

Identifiers

PMID: 10974309
DOI: 10.1016/s0028-3908(00)00066-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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