Article
Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1992
Durand G M, Gregor P, Zheng X, Bennett M V, Uhl G R, Zukin R S
Abstract excerpt
Molecular cloning identified complementary DNA species, from a rat ventral midbrain library, encoding apparent splice variants of the N-methyl-D-aspartate (NMDA) receptor NMDAR1 (which we now term NR1a). Sequencing revealed that one variant, NR1b, differs from NR1a by the presence of a 21-amino acid insert near the amino end of the N-terminal domain and by an alternate C-terminal domain in which the last 75 amino...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- Alkaloids
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Colforsin
- Diterpenes
- Enzyme Activation
- Female