Article
Primary biliary cirrhosis: contribution of HLA class II allele DR8.
The Quarterly journal of medicine - 1 Jun 1993
Gregory W L, Mehal W, Dunn A N, Cavanagh G, Chapman R, Fleming K A, Daly A K, Idle J R, James O F, Bassendine M F
Abstract excerpt
Primary biliary cirrhosis is a chronic cholestatic disease of unknown aetiology which predominantly affects middle-aged women. It is thought to be autoimmune in nature, but unlike many autoimmune diseases no clear HLA association has been described. Several studies have suggested conflicting associations with HLA class II, although a DR8 association is most frequently described. To test the hypothesis that...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Female
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- HLA-DRB3 Chains
- Humans
- Liver Cirrhosis, Biliary
- Male