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Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.

Cancer research - 15 Jan 2000

Claudio P P, Howard C M, Pacilio C, Cinti C, Romano G, Minimo C, Maraldi N M, Minna J D, Gelbert L, Leoncini L, Tosi G M, Hicheli P, Caputi M, Giordano G G, Giordano A

Abstract excerpt

The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130. Recent immunohistochemical studies of the retinoblastoma family of proteins in 235 specimens of lung cancer show the tightest inverse association between the histological grading in the most aggressive tumor types and pRb2/p130. This led us to study a panel of human lung cancers for mutations in the...

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PMID: 10667590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.PMID 10667590Read ↗

Reduced transcription of the RB2/p130 gene in human lung cancer.Semantic proximity Read ↗

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinomaSemantic proximity Read ↗

The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.Semantic proximity Read ↗

Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors.Semantic proximity Read ↗

Tumor-specific exon 1 mutations could be the 'hit event' predisposing Rb2/p130 gene to epigenetic silencing in lung cancer.Semantic proximity Read ↗

Frequent Loss of pRb2/p130 in Human Ovarian CarcinomaSemantic proximity Read ↗

Retinoblastoma Regulatory Pathway in Lung CancerSemantic proximity Read ↗

Retinoblastoma Family Proteins Have Distinct Functions in Pulmonary Epithelial Cells <i>In vivo</i> Critical for Suppressing Cell Growth and TumorigenesisSemantic proximity Read ↗

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.Semantic proximity Read ↗

Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung CarcinomaSemantic proximity Read ↗

Mutations in the retinoblastoma-related gene RB2/p130 in adult T-cell leukaemia/lymphoma.Semantic proximity Read ↗

pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent EpitheliaSemantic proximity Read ↗

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