CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

doi:10.1084/jem.179.4.1285

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Article

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

The Journal of experimental medicine - 1 Apr 1994

Yoshimoto T, Paul W E

Abstract excerpt

Injection of anti-CD3 antibodies causes prompt expression of interleukin (IL)-4, IL-2, and interferon gamma (IFN-gamma) mRNA among spleen cells. The optimal dose of anti-CD3 for such induction was 1.33 microgram/animal; lymphokine mRNA was first observed at 30 min, peaked at 90 min, and was undetectable (for IL-4) or had declined markedly by 4 h. Cells harvested from spleens of mice injected with anti-CD3 90 min...

Topics

Animals
Antibodies
Antibodies, Bacterial
Antigens
Antigens, Surface
Base Sequence
CD3 Complex
CD4-Positive T-Lymphocytes
DNA
Enterotoxins
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-4

Lectins, C-Type

Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 7908323
DOI: 10.1084/jem.179.4.1285
PMCID: PMC2191455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7908323-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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