Article
Apparent requirement for CD4+ T cells in primary anti-herpes simplex virus cytotoxic T-lymphocyte induction can be overcome by optimal antigen presentation.
Viral immunology - 1 Jan 1991
Mercadal C M, Martin S, Rouse B T
Abstract excerpt
Mice depleted in vivo of either CD4+ or CD8+ T cells were used to define the requirement for interaction between the two T subsets for the induction and maturation of a herpes simplex virus (HSV) cytotoxic T-lymphocyte (CTL) response. Whereas C3H mice generated normal CD8+ CTL in the absence of CD4+ T cells, responses were undetectable in BALB/c mice. However, the role of CD4+ T cells appeared to be to supply...
Topics
- Animals
- Antigen-Presenting Cells
- Antigens, Viral
- CD4-Positive T-Lymphocytes
- Cell Line
- Genetic Variation
- Herpes Simplex
- Hypersensitivity, Delayed
- Lymphocyte Activation
- Macrophages
- Mice