Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy?

doi:10.1111/j.1365-2249.2010.04264.x

Article

Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy?

21 Oct 2010

Abstract excerpt

The precise biological mechanisms that caused the TGN1412 clinical trial tragedy (also known as 'The Elephant Man Clinical Trial') in March 2006 remain a mystery to this day. It is assumed widely that the drug used in this trial (TGN1412) bound to CD28 on T lymphocytes and following activation of these cells, a massive 'cytokine storm' ensued, leading ultimately to multi-organ failure in all recipients. The...

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