Article
Allelotype and loss of heterozygosity around the L-myc gene locus in primary lung cancers.
Lung cancer (Amsterdam, Netherlands) - 1 May 2000
Mendoza C, Sato H, Hiyama K, Ishioka S, Isobe T, Maeda H, Hiyama E, Inai K, Yamakido M
Abstract excerpt
L-myc S-allele was reported to be associated with metastasis of lung cancer, indicating the existence of a putative tumor suppressor gene around the L-myc locus, in linkage disequilibrium. The relationship between the S-allele and inactivation of some tumor suppressor gene should be indicated by allelic loss. Therefore, we examined the association between the L-myc S-allele and loss of heterozygosity at 11 loci...
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