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Article

Generation of syngeneic anti-tumour double negative cells (CD4- CD8-), with cytotoxic activity against clones of different MHC class I expression.

Journal of immunogenetics - 1 Jan 2000

Caballero A, Garrido A, Algarra I, Perez M, Garrido F

Abstract excerpt

In vivo immunization and secondary culture techniques were used to generate cytotoxic T lymphocytes against a tumour cell clone obtained from a methylcholantrene-induced fibrosarcoma. Our CTLs differed from classical CTLs (Ly2+ and MHC restricted) in that our lymphocytes exhibited a non-MHC restricted cytotoxic activity directed to the original tumour and to other MCA-induced tumours, but have failed to...

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Identifiers

PMID: 2517950
DOI: 10.1111/j.1744-313x.1989.tb00478.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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