Article
Interleukin-2 gene-modified allogeneic tumor cells for treatment of relapsed neuroblastoma.
Human gene therapy - 10 Jun 1998
Bowman L C, Grossmann M, Rill D, Brown M, Zhong W Y, Alexander B, Leimig T, Coustan-Smith E, Campana D, Jenkins J, Woods D, Brenner M
Abstract excerpt
Tumor cells that have been genetically modified to express immunostimulatory genes will induce effective antitumor responses in a range of syngeneic animal models. For human applications, transduced autologous tumor cell lines are often difficult or impossible to prepare, so that there are strong...
Topics
- Cancer Vaccines
- Cell Transplantation
- Child
- Child, Preschool
- Cytotoxicity, Immunologic
- Genetic Therapy
- Humans
- Injections, Subcutaneous
- Interleukin-2
- Neuroblastoma
- Phenotype
- Recurrence
- Transplantation, Homologous
- Treatment Outcome
- Tumor Cells, Cultured