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Article

Dominant negative mutants of nitric oxide-sensitive guanylyl cyclase.

The Journal of biological chemistry - 14 Jan 1994

Yuen P S, Doolittle L K, Garbers D L

Abstract excerpt

Since a nitric oxide-sensitive form of guanylyl cyclase exists as a heterodimer, mutations disrupting catalysis but not heterodimer formation could serve as dominant negative mutations. Two mutations within the catalytic region of the alpha subunit (alpha 1D513A, alpha 1D529A) caused complete losses of basal and sodium nitroprusside-stimulated guanylyl cyclase activity; however, the mutant alpha subunits...

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PMID: 7904602

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