Dominant negative mutants of nitric oxide-sensitive guanylyl cyclase.

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Article

Dominant negative mutants of nitric oxide-sensitive guanylyl cyclase.

The Journal of biological chemistry - 14 Jan 1994

Yuen P S, Doolittle L K, Garbers D L

Abstract excerpt

Since a nitric oxide-sensitive form of guanylyl cyclase exists as a heterodimer, mutations disrupting catalysis but not heterodimer formation could serve as dominant negative mutations. Two mutations within the catalytic region of the alpha subunit (alpha 1D513A, alpha 1D529A) caused complete los...

Topics

Amino Acid Sequence
Animals
Binding Sites
Cyclic GMP
Genes, Dominant
Guanylate Cyclase
Macromolecular Substances
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Nitric Oxide
Nitroprusside
Precipitin Tests
Rats
Recombinant Proteins
Structure-Activity Relationship
Transfection

Source

Open in PubMed

Identifiers

PMID: 7904602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7904602-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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