Article
Dominant negative mutations of the guanylyl cyclase-A receptor. Extracellular domain deletion and catalytic domain point mutations.
The Journal of biological chemistry - 6 Jan 1995
Thompson D K, Garbers D L
Abstract excerpt
Guanylyl cyclase-A (GC-A), a receptor for A-type natriuretic peptide (ANP), contains an extracellular ligand-binding domain, a single transmembrane domain, and intracellular protein kinase-like and cyclase catalytic domains. Expression of the putative cyclase catalytic region (HCAT) resulted in t...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Catalysis
- Cell Line
- Genes, Dominant
- Guanylate Cyclase
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Point Mutation
- Receptors, Atrial Natriuretic Factor
- Receptors, Cell Surface
- Sequence Deletion