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Article

Use of chimeric forms of neuronal nitric-oxide synthase as dominant negative mutants.

IUBMB life - 1 Sept 1999

Phung Y T, Black S M

Abstract excerpt

Because the functional form of neuronal nitric-oxide synthase (nNOS) is a homodimer, we investigated whether we could disrupt dimer formation with inactive nNOS chimeras acting as dominant negative mutants. To test this hypothesis, we either expressed the heme and reductase regions of rat nNOS as single domains or produced fusion proteins between the rat nNOS heme domain and various other electron-shuttling...

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Identifiers

PMID: 10690648
DOI: 10.1080/713803520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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