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Article

Dominant negative mutants of guanylyl cyclase: probes for global functions and intramolecular mechanisms.

Methods (San Diego, Calif.) - 1 Dec 1999

Yuen P S

Abstract excerpt

Dominant negative mutants are unique tools to define functions of a protein, not only within complex cellular and organismal contexts, but also mechanistically within a protein. Guanylyl cyclases are amenable to studies with dominant negative mutants, with their own sets of opportunities for insight and pitfalls to overcome. Membrane and soluble forms of guanylyl cyclase represent self-contained signal...

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Identifiers

PMID: 10581152
DOI: 10.1006/meth.1999.0895

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Source receipt: pubmed, retrieved 7 Sept 2026.

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