Article
Heterologous desensitization of the human dopamine D1 receptor in Y1 adrenal cells and in a desensitization-resistant Y1 mutant.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1992
Olson M F, Schimmer B P
Abstract excerpt
In previous studies, mutant clones (designated Y1DR) were isolated that resisted ACTH-induced homologous desensitization of adenylyl cyclase. The Y1DR mutation also conferred resistance to the homologous desensitization induced by agonist stimulation of transfected beta 2-adrenergic receptors. These observations suggested that ACTH and beta 2-adrenergic agonists homologously desensitized adenylyl cyclase in Y1...
Topics
- 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
- Adenylyl Cyclases
- Adrenal Cortex Neoplasms
- Adrenergic beta-Agonists
- Adrenocorticotropic Hormone
- Animals
- Dopamine
- Dopamine Agents
- Drug Tolerance
- Enzyme Activation