Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterologous desensitization of the human dopamine D1 receptor in Y1 adrenal cells and in a desensitization-resistant Y1 mutant.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 1992

Olson M F, Schimmer B P

Abstract excerpt

In previous studies, mutant clones (designated Y1DR) were isolated that resisted ACTH-induced homologous desensitization of adenylyl cyclase. The Y1DR mutation also conferred resistance to the homologous desensitization induced by agonist stimulation of transfected beta 2-adrenergic receptors. These observations suggested that ACTH and beta 2-adrenergic agonists homologously desensitized adenylyl cyclase in Y1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylyl Cyclases
Share to Adrenocorticotropic Hormone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dopamine

Share to Enzyme Activation

Share to Mutation

Share to Signal Transduction

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 1354841
DOI: 10.1210/mend.6.7.1354841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterologous desensitization of the human dopamine D1 receptor in Y1 adrenal cells and in a desensitization-resistant Y1 mutant.PMID 1354841Read ↗

Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line.Semantic proximity Read ↗

Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells.Semantic proximity Read ↗

Altered G protein activity in a desensitization-resistant mutant of the Y1 adrenocortical tumor cell line.Semantic proximity Read ↗

Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.Semantic proximity Read ↗

Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.Semantic proximity Read ↗

Altered regulation of the D(1) dopamine receptor in mutant Chinese hamster ovary cells deficient in cyclic AMP-dependent protein kinase activity.Semantic proximity Read ↗

Dopamine D2 receptor-induced heterologous sensitization of adenylyl cyclase requires Galphas: characterization of Galphas-insensitive mutants of adenylyl cyclase V.Semantic proximity Read ↗

ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.Semantic proximity Read ↗

Molecular basis for the 3',5'-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells.Semantic proximity Read ↗

Analysis of the mutation to forskolin-resistance in Y1 adrenocortical tumor cells.Semantic proximity Read ↗

Decreased levels of guanyl nucleotide-binding regulatory protein alpha-subunits in Y1 adrenocortical tumor cell mutants resistant to forskolin.Semantic proximity Read ↗

Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.