Article
p53 mutation hotspot in radon-associated lung cancer.
Lancet (London, England) - 8 Jan 1994
Taylor J A, Watson M A, Devereux T R, Michels R Y, Saccomanno G, Anderson M
Abstract excerpt
Mutations in gene p53 are the most common defects in lung cancer and may be a pathway through which environmental carcinogens initiate cancer. We investigated p53 mutations in lung cancers from uranium miners with high radon exposure. 16 (31%) of 52 large-cell and squamous-cell cancers from miners contained the same AGG to ATG transversion at codon 249, including cancers from 3 or 5 miners who had never smoked....
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