Article
p53 mutations and codon 213 polymorphism of p53 in lung cancers of former uranium miners.
Journal of cancer research and clinical oncology - 1 Jan 1999
Popp W, Vahrenholz C, Schuster H, Wiesner B, Bauer P, Täuscher F, Plogmann H, Morgenroth K, Konietzko N, Norpoth K
Abstract excerpt
PURPOSE: There is a high prevalence of G-->T transversions of p53 in lung cancers of smokers. One study has reported a special "hotspot" mutation at codon 249 of p53 in lung cancers of former uranium miners. The aim of our study was to look for mutational spectra of p53 in former German uranium miners with lung cancers. METHODS: We investigated 16 patients with lung cancer who had worked as uranium miners in...
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