Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.

Abstract excerpt

Hox genes play a crucial role during embryonic patterning and organogenesis. Of the 39 Hox genes, Hoxa1 is the first to be expressed during embryogenesis and the only anterior Hox gene linked to a human syndrome. Hoxa1 is necessary for the proper development of the brainstem, inner ear and heart in humans and mice; however, almost nothing is known about the molecular downstream targets through which it exerts its...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ear, Inner
• Share to Embryo, Mammalian
• Share to Gene Targeting