Article
Construction and characterization of thrombin-resistant variants of recombinant human protein S.
Thrombosis and haemostasis - 1 Nov 1994
Chang G T, Aaldering L, Hackeng T M, Reitsma P H, Bertina R M, Bouma B N
Abstract excerpt
Protein S is a vitamin K-dependent plasma protein that functions as a cofactor of activated protein C (APC) in the inactivation of coagulation factors Va and VIIIa. Protein S, migrates as a doublet on reduced SDS polyacrylamide gel electrophoresis. This heterogeneity in molecular weight has been...
Topics
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- Carrier Proteins
- Cell Line
- Complement C4b
- Complement Inactivator Proteins
- Genetic Variation
- Glycoproteins
- Humans
- Isoleucine
- Leucine
- Molecular Sequence Data
- Protein C
- Protein S
- Receptors, Complement
- Recombinant Proteins