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Article

Protein S deficiency.

Thrombosis and haemostasis - 1 Jul 1997

Borgel D, Gandrille S, Aiach M

Abstract excerpt

The protein C (PC) pathway, with its cofactor protein S (PS), is an important natural antithrombotic mechanism. Patients with phenotypic PS deficiency may develop recurrent thrombosis during adulthood, with a probability of remaining free of thrombosis of about 50% at age 45. The molecular basis for hereditary PS deficiencies is highly heterogeneous, with a large spectrum of mutations that have various effects on...

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PMID: 9198178

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