Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S.

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Article

Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S.

Blood - 1 Feb 1994

Hayashi T, Nishioka J, Shigekiyo T, Saito S, Suzuki K

Abstract excerpt

A 29-year-old female patient with heterozygous congenital protein S deficiency suffering from thrombotic disease had normal levels of both total and free protein S antigen (70% and 65%, respectively), but low cofactor activity (31%) for activated protein C, indicating that she had a variant of pr...

Topics

Adult
Amino Acid Sequence
Base Sequence
Epidermal Growth Factor
Exons
Female
Humans
Introns
Molecular Sequence Data
Mutation
Protein Conformation
Protein S
Protein S Deficiency
Recombinant Proteins
Thrombosis

Source

Open in PubMed

Identifiers

PMID: 8298131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8298131-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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