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Article

Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S.

Blood - 1 Feb 1994

Hayashi T, Nishioka J, Shigekiyo T, Saito S, Suzuki K

Abstract excerpt

A 29-year-old female patient with heterozygous congenital protein S deficiency suffering from thrombotic disease had normal levels of both total and free protein S antigen (70% and 65%, respectively), but low cofactor activity (31%) for activated protein C, indicating that she had a variant of protein S, protein S Tokushima. Western blotting using the polyclonal anti-protein S antibody showed that approximately...

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PMID: 8298131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S.PMID 8298131Read ↗

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Construction and characterization of thrombin-resistant variants of recombinant human protein S.Semantic proximity Read ↗

Characterisation of the molecular basis of protein S anticoagulant functionSemantic proximity Read ↗

Racial differences in protein S Tokushima and two protein C variants as genetic risk factors for venous thromboembolismSemantic proximity Read ↗

Molecular basis of protein S deficiency.Semantic proximity Read ↗

A phenotypically neutral dimorphism of protein S: the substitution of Lys155 by Glu in the second EGF domain predicted by an A to G base exchange in the gene.Semantic proximity Read ↗

Protein S.Semantic proximity Read ↗

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