Article
In vitro characterisation of two naturally occurring mutations in the thrombin-sensitive region of anticoagulant protein S.
Thrombosis and haemostasis - 1 Dec 1999
Giri T K, de Frutos P G, Yamazaki T, Villoutreix B O, Dahlbäck B
Abstract excerpt
The molecular consequences of two naturally occurring mutations in the thrombin-sensitive region of protein S were investigated using a combination of recombinant protein expression, functional analysis and molecular modelling. Both mutations (R49H and R70S) have been found in thrombosis patients diagnosed as having type I protein S deficiency. Molecular modelling analysis suggested the R49H substitution not to...
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