Protein S deficiency: a clinical perspective.

doi:10.1111/j.1365-2516.2008.01775.x

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Article

Protein S deficiency: a clinical perspective.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Nov 2008

ten Kate M K, van der Meer J

Abstract excerpt

Protein S (PS) is an extensively studied protein with an important function in the down-regulation of thrombin generation. Because of the presence of a pseudogene and two different forms of PS in plasma, a bound and a free form, it is one of the most difficult thrombophilias to study. A deficiency of PS predisposes subjects to (recurrent) venous thromboembolism (VTE) and foetal loss. However, the conundrum of...

Topics

Adult
Age of Onset
Anticoagulants
Blood Coagulation Tests
Blood Proteins
Contraceptives, Oral, Hormonal
Contraindications
Estrogen Replacement Therapy
False Positive Reactions
Female
Heterozygote
Humans
Immunoassay
Infant, Newborn
Male
Middle Aged
Mutation
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 18479427
DOI: 10.1111/j.1365-2516.2008.01775.x

Provenance

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