Article
DNA sequence requirements for Ah receptor/Arnt recognition determined by in vitro transcription.
Receptor - 1 Jan 1994
McLane K E, Whitlock J P
Abstract excerpt
The enhancer of the mouse cytochrome P450 cyp1a1 gene, which contains six binding sites (A-F) for the Ah receptor (AhR), has been a useful model system for studying the mechanism of AhR-mediated activation of transcription. In the presence of ligand, AhR interacts with its dimerization partner, A...
Topics
- Amino Acid Sequence
- Animals
- Aryl Hydrocarbon Receptor Nuclear Translocator
- Base Sequence
- Binding Sites
- Binding, Competitive
- Consensus Sequence
- Cytochrome P-450 Enzyme System
- DNA-Binding Proteins
- Helix-Loop-Helix Motifs
- In Vitro Techniques
- Mice
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Receptors, Aryl Hydrocarbon
- Transcription Factors
- Transcriptional Activation