Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

Article

Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

The Journal of biological chemistry - 5 Apr 1992

Shen E S, Whitlock J P

Abstract excerpt

The liganded Ah receptor activates transcription by binding to a specific DNA-recognition motif within a dioxin-responsive enhancer upstream of the CYP1A1 gene. Analyses of mutant enhancers by gel retardation reveal that each base pair within the domain 5'CGTG(GCAC)3' is essential to the receptor...

Topics

Base Sequence
Binding Sites
DNA
DNA-Binding Proteins
Enhancer Elements, Genetic
Ligands
Molecular Sequence Data
Mutation
Polychlorinated Dibenzodioxins
Receptors, Aryl Hydrocarbon
Receptors, Drug

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