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Article

Altered DNA binding specificity of Arnt by selection of partner bHLH-PAS proteins.

Nucleic acids research - 1 Jan 2004

Kinoshita Koshi, Kikuchi Yasuo, Sasakura Yukie, Suzuki Masashi, Fujii-Kuriyama Yoshiaki, Sogawa Kazuhiro

Abstract excerpt

The Ah receptor (AhR) and HLF are transcription factors involved in xenobiotic metabolism and hypoxic response, respectively. AhR and HLF heterodimerize with Arnt as the common partner, and bind to asymmetric E-boxes termed XRE and HRE, respectively. In order to investigate nucleotide preference of the heterodimers, reporter plasmids with oligonucleotides for XREs or HREs with systematic mutations were...

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Source

Open in PubMed Open full text

Identifiers

PMID: 15190133
DOI: 10.1093/nar/gkh637
PMCID: PMC434443

Genes

HLF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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