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Article

Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity.

Archives of biochemistry and biophysics - 1 Oct 2005

Murray Iain A, Reen Rashmeet K, Leathery Nathan, Ramadoss Preeti, Bonati Laura, Gonzalez Frank J, Peters Jeffrey M, Perdew Gary H

Abstract excerpt

The aryl hydrocarbon receptor (AhR) mediates the biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Whether the AhR can mediate enhanced transcriptional activity in the absence of ligand binding has not been established. Hepatocytes from AhR-null (AhR-KO) and wild-type (AhR-WT) neonatal mice were immortalized with Simian virus 40. Two point mutants of the AhR, A375I and A375F, were generated to test the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16137638
DOI: 10.1016/j.abb.2005.07.014

Genes

ARNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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