Article
AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation.
Molecular and cellular biology - 1 Apr 1995
Datta K, Franke T F, Chan T O, Makris A, Yang S I, Kaplan D R, Morrison D K, Golemis E A, Tsichlis P N
Abstract excerpt
The cytoplasmic serine-threonine protein kinase coded for by the c-akt proto-oncogene features a protein kinase C-like catalytic domain and a unique NH2-terminal domain (AH domain). The AH domain is a member of a domain superfamily whose prototype was observed in pleckstrin (pleckstrin homology,...
Topics
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Enzyme Activation
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-akt
- Recombinant Proteins
- Saccharomyces cerevisiae
- Structure-Activity Relationship