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Article

Progression to AIDS in the absence of a gene for vpr or vpx.

Journal of virology - 1 Apr 1995

Gibbs J S, Lackner A A, Lang S M, Simon M A, Sehgal P K, Daniel M D, Desrosiers R C

Abstract excerpt

Rhesus monkeys (Macaca mulatta) were experimentally infected with strains of simian immunodeficiency virus (SIV) derived from SIVmac239 lacking vpr, vpx, or both vpr and vpx genes. These auxiliary genes are not required for virus replication in cultured cells but are consistently conserved within...

Topics

Animals
Antibodies, Viral
Cell Line
Genes, vpr
Macaca mulatta
Molecular Sequence Data
Oligodeoxyribonucleotides
Phenotype
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
Viral Regulatory and Accessory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7884883
DOI: 10.1128/JVI.69.4.2378-2383.1995
PMCID: PMC188910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7884883-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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