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Article

Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus

1 Feb 1993

Abstract excerpt

The importance of the vpr gene for simian immunodeficiency virus (SIV) replication, persistence, and disease progression was examined by using the infectious pathogenic molecular clone called SIVmac239. The ATG start codon of the vpr gene was converted to TTG by site-specific mutagenesis. The constructed Vpr- mutant virus is identical with the parental SIVmac239/nef-stop virus with the exception of this one...

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PMID: 8380472
DOI: 10.1128/jvi.67.2.902-912.1993

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