Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS.

Article

Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS.

The American journal of pathology - 1 Jul 1991

Desrosiers R C, Hansen-Moosa A, Mori K, Bouvier D P, King N W, Daniel M D, Ringler D J

Abstract excerpt

The importance of macrophage infection for the development of acquired immune deficiency syndrome (AIDS) was investigated. Molecularly cloned simian immunodeficiency virus (SIV)mac239 replicates very poorly in cultured macrophages yet it causes AIDS in rhesus monkeys. Three of five rhesus monkeys...

Topics

Animals
Genetic Variation
Macaca mulatta
Macrophages
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
Virus Replication

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