Article
SIV infection of macaques as a model for AIDS pathogenesis.
International reviews of immunology - 1 Jan 1992
Johnson P R, Hirsch V M
Abstract excerpt
Simian immunodeficiency virus (SIV) infection of macaques is the best available animal model for studying the pathogenesis of AIDS. Experimental inoculation of macaques with SIV results in a persistent infection that leads to immunodeficiency, opportunistic infections, and death. Most aspects of the illness, including immunologic and virologic parameters, are easily quantified. Furthermore, pathologic processes...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- Chimera
- Cloning, Molecular
- Disease Models, Animal
- Genetic Variation
- Macaca mulatta
- Molecular Biology
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus