Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742.

doi:10.1128/AAC.01132-07

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Article

Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742.

Antimicrobial agents and chemotherapy - 1 Apr 2008

Dekhtyar Tatyana, Ng Teresa I, Lu Liangjun, Masse Sherie, DeGoey David A, Flosi William J, Grampovnik David J, Klein Larry L, Kempf Dale J, Molla Akhteruzzaman

Abstract excerpt

A-790742 is a potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor, with 50% effective concentrations ranging from 2 to 7 nM against wild-type HIV-1. The activity of this compound is lowered by approximately sevenfold in the presence of 50% human serum. A-790742 maintained potent antiviral activity against lopinavir-resistant variants generated in vitro as well as against a panel of molecular...

Topics

Drug Resistance, Viral
HIV Protease
HIV Protease Inhibitors
HIV-1
Humans
Lopinavir
Microbial Sensitivity Tests
Mutation
Phenotype
Pyrimidinones
Selection, Genetic
Serial Passage

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Identifiers

PMID: 18212102
DOI: 10.1128/AAC.01132-07
PMCID: PMC2292532

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