Article
In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1993
Otto M J, Garber S, Winslow D L, Reid C D, Aldrich P, Jadhav P K, Patterson C E, Hodge C N, Cheng Y S
Abstract excerpt
Protease inhibitors are another class of compounds for treatment of human immunodeficiency virus (HIV)-caused disease. The emergence of resistance to the current anti-HIV drugs makes the determination of potential resistance to protease inhibitors imperative. Here we describe the isolation of an HIV type 1 (HIV-1) resistant to an HIV-protease inhibitor. Serial passage of HIV-1 (strain RF) in the presence of the...
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