Article
In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1993
Otto M J, Garber S, Winslow D L, Reid C D, Aldrich P, Jadhav P K, Patterson C E, Hodge C N, Cheng Y S
Abstract excerpt
Protease inhibitors are another class of compounds for treatment of human immunodeficiency virus (HIV)-caused disease. The emergence of resistance to the current anti-HIV drugs makes the determination of potential resistance to protease inhibitors imperative. Here we describe the isolation of an...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Cloning, Molecular
- Codon
- DNA, Viral
- Genetic Variation
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Molecular Sequence Data
- Molecular Structure
- Mutagenesis, Site-Directed