Article
A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor SC-55389A.
Antimicrobial agents and chemotherapy - 1 Mar 1997
Smidt M L, Potts K E, Tucker S P, Blystone L, Stiebel T R, Stallings W C, McDonald J J, Pillay D, Richman D D, Bryant M L
Abstract excerpt
The hydroxyethylurea human immunodeficiency virus type 1 (HIV-1) protease inhibitors SC-55389A and SC-52151 were used to select drug-resistant variants in vitro. One clinical HIV-1 strain (89-959) and one laboratory HIV-1 strain (LAI) were passaged in peripheral blood mononuclear cells or CEMT4 c...
Topics
- Amino Acid Sequence
- Cloning, Molecular
- Drug Resistance, Microbial
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Models, Molecular
- Molecular Conformation
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Polymerase Chain Reaction