Article
In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor.
Journal of virology - 1 Sept 1998
Carrillo A, Stewart K D, Sham H L, Norbeck D W, Kohlbrenner W E, Leonard J M, Kempf D J, Molla A
Abstract excerpt
ABT-378, a new human immunodeficiency virus type 1 (HIV-1) protease inhibitor which is significantly more active than ritonavir in cell culture, is currently under investigation for the treatment of AIDS. Development of viral resistance to ABT-378 in vitro was studied by serial passage of HIV-1 (...
Topics
- Amino Acid Sequence
- Animals
- Anti-HIV Agents
- Binding Sites
- COS Cells
- Cell Line, Transformed
- Drug Resistance, Microbial
- Genetic Variation
- HIV Protease
- HIV-1
- Humans
- Lopinavir
- Molecular Sequence Data
- Molecular Structure
- Mutation