Article

Exploiting the adenoassociated virus Rep protein to mediate site-specific integration into the human genome and optimisation of Ad/AAV vector design

2008-01-01

Abstract excerpt

Gene therapy is an approach to treating diseases in which an exogenous gene is introduced to correct for a defective or missing protein or to affect a biochemical pathway. Few successes have been reported in humans (0), as several technical issues limit its broader application. One question is how to deliver DNA to the appropriate cells. Nature provides one solution in the form of viruses, which are in essence pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e90783f-43dd-50c1-8f3d-8ed5f0b0d276
DOI: 10.21954/ou.ro.0000fa68

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploiting the adenoassociated virus Rep protein to mediate site-specific integration into the human genome and optimisation of Ad/AAV vector designDOI 10.21954/ou.ro.0000fa68Read

Genome engineering using Adeno-Associated Virus (AAV).Semantic proximity Read

AAV- based vector improvements unrelated to capsid protein modificationSemantic proximity Read

Evaluating the state of the science for adeno-associated virus integration: An integrated perspectiveSemantic proximity Read

Adeno-associated virus Type 2 Rep proteins mediate integration of lentiviral vectorsSemantic proximity Read

Adeno-Associated Virus (AAV) as a Vector for Gene TherapySemantic proximity Read

Fate of recombinant adeno-associated viral vector genomes during DNA double-strand break-induced gene targeting in human cells.Semantic proximity Read

Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research ApplicationsSemantic proximity Read

Modulation of the cellular phenotype by integrated adeno-associated virus.Semantic proximity Read

Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6Semantic proximity Read

Integration Preferences of Wildtype AAV-2 for Consensus Rep-Binding Sites at Numerous Loci in the Human GenomeSemantic proximity Read

Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep proteinSemantic proximity Read

Site-specific integration by adeno-associated virus.Semantic proximity Read