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Article

Consistency and stability of recombinant fermentations.

Developments in biological standardization - 1 Jan 1994

Wiebe M E, Builder S E

Abstract excerpt

Production of proteins of consistent quality in heterologous, genetically-engineered expression systems is dependent upon identifying the manufacturing process parameters which have an impact on product structure, function, or purity, validating acceptable ranges for these variables, and performing the manufacturing process as specified. One of the factors which may affect product consistency is genetic...

Topics

Biotechnology
DNA, Recombinant
Fermentation
Gene Amplification
Humans
Molecular Structure
Mutation
Peptide Mapping
Protein Engineering
Quality Control
Recombinant Proteins
Tissue Plasminogen Activator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7883099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7883099-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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