Article
Genetic and phenotypic markers and their relationship to product quality and consistency.
Developments in biological standardization - 1 Jan 1994
Adamson S R, Charlebois T S
Abstract excerpt
Manufacturers of products derived from biological systems have long sought to identify relevant genotypic and phenotypic markers displayed by production strains and cell lines which could be employed as in-process monitors to predict product quality. Ideally, changes in these markers would signal possible changes in product quality and could be used to ensure batch to batch product consistency. In mammalian cell...
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